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Symbol
Name
ID

Ret
ret proto-oncogene
MGI:97902

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Elevated urinary vanillylmandelic acid

Proteinuria

Elevated urinary dopamine level

Elevated urinary epinephrine level

Elevated urinary norepinephrine level

Renal artery stenosis

Vesicoureteral reflux

Urethral valve

Abnormal renal morphology

Pelvic kidney

Glomerulomegaly

Abnormal renal tubule morphology

Decreased numbers of nephrons

Abnormal renal cortex morphology

Hydronephrosis

Unilateral renal agenesis

Renal insufficiency

Chronic kidney disease

Abnormality of the ureter

Recurrent urinary tract infections

Disease(s) Associated with RET

multiple endocrine neoplasia type 2A

multiple endocrine neoplasia type 2B

pheochromocytoma

renal hypoplasia

Mouse Phenotypes

renal/urinary system phenotype

increased metanephric mesenchyme apoptosis

increased kidney apoptosis

kidney cyst

abnormal kidney morphology

abnormal kidney collecting duct morphology

dilated renal glomerular capsule

abnormal renal glomerulus morphology

glomerulosclerosis

decreased renal glomerulus number

absent kidney cortex

abnormal kidney development

abnormal kidney medulla development

abnormal kidney mesenchyme morphology

abnormal metanephric mesenchyme morphology

absent nephrogenic zone

absent kidney medulla

hydronephrosis

decreased kidney weight

small kidney

kidney atrophy

renal hypoplasia

dilated renal tubule

renal cast

absent kidney

ectopic kidney

single kidney

abnormal ureter morphology

abnormal ureter development

absent ureter

blind ureter

dilated ureter

large ureter

ureter obstruction

ureter stenosis

abnormal urinary bladder morphology

abnormal ureteric bud morphology

abnormal branching involved in ureteric bud morphogenesis

impaired branching involved in ureteric bud morphogenesis

abnormal ureteric bud elongation

abnormal ureteric bud invasion

ectopic ureteric bud

Availability

Mouse Genotype

Ret^tm1.2Pern/Ret^tm1.2Pern

Ret^tm1Cos/Ret^tm1Cos

Ret^tm1Cti/Ret^tm1Cti

Ret^tm1Giro/Ret^tm1Giro

Ret^tm1Jmi/Ret^tm1Jmi

Ret^tm1Mat/Ret^tm1Mat

Ret^tm2.1Heno/Ret^tm2.1Heno

Ret^tm2Cos/Ret^tm2Cos

Ret^tm4(RET)Jmi/Ret^tm4(RET)Jmi

Ret^tm7(RET)Jmi/Ret^tm7(RET)Jmi

Ret^tm8(RET)Jmi/Ret^tm8(RET)Jmi

Ret^tm9(RET)Jmi/Ret^tm9(RET)Jmi

Ret^tm10(RET)Jmi/Ret^tm10(RET)Jmi

*

Ret^tm11(RET)Jmi/Ret^tm11(RET)Jmi

Ret^tm12(RET)Jmi/Ret^tm12(RET)Jmi

Ret^tm13.1Jmi/Ret^tm13.1Jmi

Ret^tm1Cos/Ret⁺

Ret^tm1Jmi/Ret⁺

Ret^{tm3.1(RET)Jmi}/Ret⁺

Ret^tm9(RET)Jmi/Ret^tm12(RET)Jmi

*

Nkx6-2^tm2(cre)Ercs/Nkx6-2⁺
Ret^tm1.1Pern/Ret^tm1.1Pern (conditional)

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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